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Article
November 1953

EFFECT OF HYALURONIDASE ON NEW VESSEL FORMATION IN THE CORNEAAn Experimental Study

Author Affiliations

HAIFA, ISRAEL

AMA Arch Ophthalmol. 1953;50(5):613-617. doi:10.1001/archopht.1953.00920030623009
Abstract

THE PRESENCE of hyaluronidase and its substrate in various tissues of the eye and their role in regulating the exchange of metabolites and water by influencing barriers existing at internal interfaces (Meyer,1 1947) have stimulated work on the eyes of men and animals within recent years.

If hyaluronidase is injected intraocularly in the rabbit, there results a prolonged inflammatory reaction (Pirie,2 1949; von Sallmann,3 1950; Linn and Ozment,4 1950). Its ability to increase the permeability of the lens capsule has been reported (Seifter and associates,5 1950). Hyaluronidase has no specific effect on the disappearance of red blood corpuscles from the vitreous of rabbits (von Sallmann3). It has been used to increase the effect of anesthetics injected retrobulbarly (Atkinson,6 1949). It has been instilled, with only temporary benefit but without severe reaction, into the anterior chamber of two patients with secondary glaucoma (Linn and

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