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Article
December 1953

NATURE OF THE CORNEAL "CANALS" PRODUCED BY PERILIMBAL INJECTIONS OF HYDROGEN PEROXIDE

AMA Arch Ophthalmol. 1953;50(6):688-695. doi:10.1001/archopht.1953.00920030699003
Abstract

ATTEMPTS at outlining corneal channels have been numerous and are well known, but no unimpeachable results have thus far been obtained. The most frequently quoted are the experiments of von Recklinghausen in staining the superficial corneal layers with silver and the efforts of Bowman to inject the stroma with metallic mercury. In 1909 Krusius1 utilized oxygen liberated in situ on injection of hydrogen peroxide (H2O2) in the perilimbal region of the rabbit's eye to force open what he thought were corneal lymphatics. He described a snow-white ring at the limbus from which the gas infiltrated the cornea in rows of bubbles. He considered these spaces to be "preformed" and stated that they were lined with endothelium. Later, Magnus2 extended this principle to other tissues of the body as well as the eye, but only his findings in connection with the cornea are of primary interest

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