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Article
December 1953

EVALUATION OF WOUNDS OF THE RABBIT CORNEA TREATED WITH CALSULFHYDRYL (HYDROSULPHOSOL)

Author Affiliations

MINNEAPOLIS

AMA Arch Ophthalmol. 1953;50(6):696-698. doi:10.1001/archopht.1953.00920030707004
Abstract

SINCE 1942 several clinical investigations have been published describing the increased healing rate of corneal wounds treated with calsulfhydryl (Hydrosulphosol1). This sulfhydryl solution has been reported by Mellon,2 Cruthirds3, Pierce,4 Mullen,5 and Kuhn6 to be highly effective but it was used clinically by these authors without controls. Efforts have therefore been made to confirm these clinical observations by carefully controlled chemical injuries inflicted on rabbit corneas, but these attempts have been mostly unsuccessful. In a large series of rabbits reported by Harley7 there was no demonstrable increase in rate of healing in corneas injured with acids and alkalies when calsulfhydryl was used, and, in an earlier article, Williams and Bissel8 were also unable to increase healing with sulfhydryl solutions.

The present study was undertaken therefore to evaluate the effect of calsulfhydryl on a controlled series of rabbits corneas injured by abrasion or by

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