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February 1954


Author Affiliations

From the Palo Alto Clinic.

AMA Arch Ophthalmol. 1954;51(2):229-241. doi:10.1001/archopht.1954.00920040231010

INFECTIOUS mononucleosis has become of increasing importance, particularly since the introduction of the heterophile agglutination test in 1932. The establishment of the pathologic picture of infectious mononucleosis has awakened the medical profession to the numerous problems associated with the disease. Among these are its high incidence rate, prolonged disability, and the multiple and varied manifestations of involvement of nearly every organ system of the body. Some results are permanent; death may occur.

To the present time there has been little recognition of the disease by ophthalmologists. Accounts in the American ophthalmological literature regarding any of the multiple manifestations which concern the eye apparently are confined to one report1 of bilateral papilloretinal edema. Patients recently seen with ocular involvement of infectious mononucleosis stimulated this study.

Infectious mononucleosis is an acute, usually self-limited infectious disease of unknown etiology, characterized more commonly by fever, lymphadenopathy, acute respiratory tract symptoms, and the presence

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