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April 1954


Author Affiliations

From the Wills Eye Hospital, Department of Research; Irving H. Leopold, M.D., Director.

AMA Arch Ophthalmol. 1954;51(4):535-548. doi:10.1001/archopht.1954.00920040545012

ONE OF the important features of drug evaluation in ophthalmology is the experimental creation of lesions in animals which are standard, reproducible, and similar in location and appearance to those found in humans. With few exceptions,* studies of bacterial lesions and tumor transplants have been confined to the anterior segment. In contrast, a large number of conditions begin in or are confined to the posterior segment in humans. The present study has been done to show the potentialities of the posterior segment as a source of experimental lesions and to demonstrate a method of producing them.

The fundus of the rabbit eye is particularly accessible because of the soft orbital wall and the ease with which the eye can be proptosed painlessly. It has previously been shown † that the suprachoroidal space of the rabbit is readily separated from the sclera. It was felt that various fluids could be injected

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