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June 1954


Author Affiliations

From the Department of Pathology (Prof. P. Gerard), the Ophthalmic Clinic (Prof. L. Coppez), and the Medical Clinic (Prof. P. Govaerts), of the University of Brussels.

AMA Arch Ophthalmol. 1954;51(6):799-810. doi:10.1001/archopht.1954.00920040809007

DISSEMINATED lupus erythematosus is a febrile, usually fatal, disease involving the ground substance of connective tissue. It may attack any organ of the body, and thereby gives rise to an extremely polymorphic group of symptoms.

Because of this generalized predilection for connective tissue, Klemperer, Pollack, and Baehr have classified disseminated lupus erythematosus as a "collagen disease," along with rheumatic fever, rheumatoid arthritis, periarteritis nodosa, generalized scleroderma, and dermatomyositis. Klemperer has emphasized that this classification is purely a morphologic one; it has no pathogenetic significance and does not imply that these conditions have a common etiology.

Disseminated lupus erythematosus must be distinguished from tuberculous lupus and discoid lupus (lupus erythematosus discoides), which are purely dermatologic conditions.

Reference to ocular lesions with lupus erythematosus is infrequent, and the cases which have been confirmed by histologic examination are very rare.

The case of lupus erythematosus to be reported here is that of a

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