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Article
July 1954

REMOVAL RATE OF RADIOSODIUM (Na24) FROM HUMAN ORBIT IN GRAVES'S DISEASE AND IN HEALTH

Author Affiliations

With the Technical Assistance of Argiry Cavaris, B.A. NEW YORK
From the Departments of Ophthalmology and Medicine, Columbia University College of Physicians and Surgeons and the Presbyterian Hospital.

AMA Arch Ophthalmol. 1954;52(1):85-90. doi:10.1001/archopht.1954.00920050087010
Abstract

THE MECHANISMS responsible for the production and maintenance of the ocular complications of hyperthyroidism have not been entirely elucidated. Accordingly, the rate of removal of radioactive sodium from the orbits of healthy human subjects and of patients with the mild and severe extremes of ophthalmopathy has been observed with a view toward determining whether venous obstruction or active inflammation accounts for the phenomena. The extremes of the eye changes have been variously termed "thyrotoxic" and "thyrotropic," or "simple" and "malignant" exophthalmos, among other names, but in this paper they will be called "mild" and "severe."

It has been recognized that orbital tension is increased in the severe form of thyroid ophthalmopathy. Quantitative measurements reveal an increase proportionate to the degree of exophthalmos.1 Rundle and Pochin2 have shown also that there is a significant increase in orbital bulk which tends to correlate quantitatively with the degree of exophthalmos. This

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