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Article
November 1954

INTRAOCULAR PENETRATION OF LOCAL HYDROCORTISONE AND CORTISONE

Author Affiliations

PHILADELPHIA
From the Department of Research, Wills Eye Hospital.

AMA Arch Ophthalmol. 1954;52(5):769-773. doi:10.1001/archopht.1954.00920050775013
Abstract

THE EXPERIMENTS to be reported in this paper were undertaken for the purpose of determining steroid levels in the aqueous humor following subconjunctival injections or topical applications of cortisone acetate or hydrocortisone acetate.*

The results of such studies were reported earlier from this laboratory t and by others.‡ The results were similar, but because of certain difficulties and inadequacies of the methods employed, discussed in a later paper from this laboratory,5 it was deemed of importance to reinvestigate this problem, using certain essential modifications in the analytical methods.

METHODS  Adult rabbits, approximately 4 lb. (1.8 kg.) in weight, were used. The aqueous humor was removed with a 26-gauge needle and tuberculin syringe by means of an oblique corneal puncture The eyes were previously anesthetized by the instillation of two drops of 0.5% tetracaine hydrochloride and were thoroughly flushed with isotonic saline before the aqueous humor specimens were removed for

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