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Article
December 1954

FREQUENCY OF RETINOBLASTOMA IN THE PROGENY OF PARENTS WHO HAVE SURVIVED THE DISEASE

AMA Arch Ophthalmol. 1954;52(6):815-818. doi:10.1001/archopht.1954.00920050821001
Abstract

TWO QUESTIONS of genetic interest in relation to retinoblastoma are posed the ophthalmologist. First, when retinoblastoma has occurred in one child of healthy parents, what is the likelihood that further siblings will be affected? Second, is it advisable for the adult survivor of retinoblastoma to have children?

In an effort to answer these questions, in 1949 I1 reported the results of an analysis made from the follow-up of 91 cases. For the purpose of this analysis, we communicated with 171 consecutive cases, and we were successful in receiving the desired data on 91.

Eighty-six of our 91 cases were sporadic (no relative of the child having had the disease and the parents both having normal eyes), and 60 of these had siblings totaling 103. Only 1 sibling of these 103 had retinoblastoma. We could find in the literature only two other series (those of Reiser and of Hemmes) in

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