CHELATING agents (χηλ[unk], claw) are compounds which, by forming soluble complexes with specific metals or compounds, remove them from the chemical milieu in which they occur, thus extracting, or clawing, them out.
This process can be demonstrated both in solutions and in tissues, affording us a useful tool in research and therapy. Grant1 (1952) reported on the use of the neutral sodium salt of ethylenediamine-tetraacetic acid, edathamil calcium-disodium (EDTA *) in the chelation of calcium from corneas exhibiting band keratopathy. Significant clearing was accomplished with 0.01 or 0.05 M. solutions applied in drop fashion for about 15 minutes to the previously deepithelized corneas. The calcific component of an opacity could be removed, but actual scarring, inflammatory infiltration, or vascularization was unaffected. The visual result, therefore, depended on the proportion of these components in the corneal lesion and upon any deeper alterations present in the eye.
Band keratopathy is usually associated with
BREININ GM, DE VOE AG. CHELATION OF CALCIUM WITH EDATHAMIL CALCIUM-DISODIUM IN BAND KERATOPATHY AND CORNEAL CALCIUM AFFECTIONS. AMA Arch Ophthalmol. 1954;52(6):846-851. doi:10.1001/archopht.1954.00920050852005