[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.176.30. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
December 1954

CHELATION OF CALCIUM WITH EDATHAMIL CALCIUM-DISODIUM IN BAND KERATOPATHY AND CORNEAL CALCIUM AFFECTIONS

Author Affiliations

NEW YORK
From the Department of Ophthalmology of the New York University Postgraduate School of Medicine-Bellevue Hospital Center.

AMA Arch Ophthalmol. 1954;52(6):846-851. doi:10.1001/archopht.1954.00920050852005
Abstract

CHELATING agents (χηλ[unk], claw) are compounds which, by forming soluble complexes with specific metals or compounds, remove them from the chemical milieu in which they occur, thus extracting, or clawing, them out.

This process can be demonstrated both in solutions and in tissues, affording us a useful tool in research and therapy. Grant1 (1952) reported on the use of the neutral sodium salt of ethylenediamine-tetraacetic acid, edathamil calcium-disodium (EDTA *) in the chelation of calcium from corneas exhibiting band keratopathy. Significant clearing was accomplished with 0.01 or 0.05 M. solutions applied in drop fashion for about 15 minutes to the previously deepithelized corneas. The calcific component of an opacity could be removed, but actual scarring, inflammatory infiltration, or vascularization was unaffected. The visual result, therefore, depended on the proportion of these components in the corneal lesion and upon any deeper alterations present in the eye.

Band keratopathy is usually associated with

First Page Preview View Large
First page PDF preview
First page PDF preview
×