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Article
April 1955

Studies on experimental Glaucoma

Author Affiliations

Philadelphia
From the Research Department of Wills Eye Hospital.

AMA Arch Ophthalmol. 1955;53(4):487-494. doi:10.1001/archopht.1955.00930010489005
Abstract

The aim of the present investigation is the study of experimentally induced glaucoma in the rabbit and the influence of iridectomy on its course. The normal intraocular pressure can be raised (a) by decreasing the aqueous drainage or (b) by increasing the rate of fluid production.

  1. Diminished aqueous outflow has been achieved by mechanical blockage of the filtration angle. This can be accomplished in the following ways: (a) by injecting oils and colloids that hinder the outflow of aqueous at the angle of the anterior chamber1; (b) by producing an inflammatory response at the angle, with ultimate development of synechiae1; (c) by developing a proliferative endothelial reaction at the angle by means of electrolytic products,1 and (d) by occlusion of the pupil, which also leads to mechanical blockage of the angle of the anterior chamber. Interruption of the aqueous circulation at the pupil has been produced by obstructing

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