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April 1955

Experimental Leptospiral Uveitis in Rabbits

Author Affiliations

New York
From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

AMA Arch Ophthalmol. 1955;53(4):547-559. doi:10.1001/archopht.1955.00930010555015

The results of previous clinical and experimental work with horses suffering from periodic ophthalmia strongly suggest that this uveitis is due to Leptospira pomona and L. grippotyphosa infection,* although the leptospiral nature of periodic ophthalmia could be proved by culture in only a few cases. Hertel3 (1917) produced uveitis in rabbits by injecting suspensions of Leptospira icterohaemorrhagiae into the vitreous and into the anterior chamber. Gsell4 reported leptospiral infections in humans, with an occasional involvement of the uvea. These authors did not conduct any serological studies on aqueous humor. Recent experimental data on horses suffering from periodic ophthalmia provided strong evidence of local antibody formation. Similar results were obtained in experimental tuberculous uveitis in rabbits.6 Since it has been reported5 that rabbits, generally resistant to systemic leptospiral infection, have high antibody titers, this test lesion appeared to be especially suited to the investigation of local antibody

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