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Article
April 1955

INTRAOCULAR PENETRATION OF LOCAL HYDROCORTISONE AND CORTISONE

Author Affiliations

133 E. 58th St. New York 22

AMA Arch Ophthalmol. 1955;53(4):615-616. doi:10.1001/archopht.1955.00930010623027

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Abstract

To the Editor:  —Weimar and Leopold, in a very constructive article in the November, 1954, issue of the Archives, point out that hydrocortisone acetate injected subconjunctivally did not penetrate the eye in high levels, with the test employed.In my article in the American Journal of Ophthalmology in April, 1954, it was pointed out that "hydrocortisone acetate was inferior to the free-alcohol form of hydrocortisone in the treatment of eye disease by subconjunctival injection. A combination of the hydrocortisone acetate and free-alcohol form of hydrocortisone has proven very satisfactory."Experience with systemic hydrocortisone indicates a superiority over cortisone in intraocular inflammations. Peculiarly enough, hydrocortisone acetate has a marked superiority over the virtually inactive cortisone acetate when employed as an ointment in the treatment of dermatological conditions of the skin or mucous membranes.The inferiority of hydrocortisone acetate to cortisone acetate by subconjunctival injection may be due to one of many

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