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Article
June 1955

pHisoHex Keratitis

Author Affiliations

Dallas, Texas
From the Division of Ophthalmology, Southwestern Medical School of University of Texas.

AMA Arch Ophthalmol. 1955;53(6):817-824. doi:10.1001/archopht.1955.00930010825006
Abstract

pHisoHex (pHisoderm with hexachlorophene) is widely used as a preoperative cleansing agent for ocular surgery. A review of the literature revealed no reports pertinent to the effects, favorable or unfavorable, of this bactericide upon the human cornea.

Our recent experience with the use of pHisoHex as a preoperative cleansing agent for the face and lids indicates that this preparation is capable of inducing chemical injury to the corneal tissues.

A study of pHisoHex keratitis is presented in three sections:

  • Report of clinical cases of pHisoHex keratitis

  • Observations on pHisoHex induced keratitis in the rabbit and dog

  • Histopathology of pHisoHex keratitis in the rabbit and dog

I. REPORT OF CLINICAL CASES OF pHisoHex KERATITIS  Following are the clinical reports of two cases of deep keratitis which developed in adult patients following the chance introduction of small amounts of pHisoHex into the companion eye during the preoperative cleansing of

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