It has been generally assumed that the glucose metabolism in the lens is similar to that which predominates in other tissues. In most mammalian tissues glucose is catabolized first anaerobically to lactic acid by a process known as the glycolytic pathway and thence aerobically to carbon dioxide by a process known as the citric acid cycle. But the peculiar avascularity of the lens and its low oxygen consumption do not allow one to make any a priori assumptions as to the utilization of glucose by the lens. It is known that oxygen is essential for the maintenance of the viability of the lens,1 but heretofore no study has been made of pathways in the lens other than the classical types just referred to.
The present paper reports a study of aerobic pathways of carbohydrate metabolism and a quantitative evaluation of their relative importance. It will be pointed out that
KINOSHITA JH. Carbohydrate metabolism of Lens. AMA Arch Ophthalmol. 1955;54(3):360-368. doi:10.1001/archopht.1955.00930020366005