The present study was undertaken with the object of determining whether the progression of cataract formation, when the latter is induced by diabetes, might be altered by the following procedures: (a) feeding of diets containing an excess of nicotinic acid, (b) the injection of cysteine, or (c) maintenance of the animals in an atmosphere of 38%-40% oxygen. In addition, a comparison has been made of cataract formation in rats and rabbits as observed with the ophthalmoscope. In order to verify and supplement these observations, the lenses have been studied histologically.
In a previous publication1 it was noted that when diets containing excess nicotinic acid were fed to diabetic rats there was some delay in cataract formation. This could have resulted either from a lower food intake of the nicotinic-acid-fed group or from some effect of the nicotinic acid per se. In the present study the paired-feeding method was used
BOUNDS GW, JANES RG, LEINFELDER PJ. Cataracts Induced by Alloxan Diabetes in Rats and RabbitsExperimental Studies. AMA Arch Ophthalmol. 1955;54(4):564-572. doi:10.1001/archopht.1955.00930020570009