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December 1955

The Effect of a Barbiturate and Paraldehyde on Aqueous Humor Dynamics in Rabbits

Author Affiliations

Baltimore; Liége, Belgium
From the Wilmer Ophthalmological Institute of The Johns Hopkins University and Hospital, Baltimore.

AMA Arch Ophthalmol. 1955;54(6):834-840. doi:10.1001/archopht.1955.00930020840004

In a previous study from this laboratory, Kornbluth and Linnér1 demonstrated the possibility and utility of tonography in rabbits. Their experiments were performed under barbiturate (pentobarbital [Nembutal] ) anesthesia. Subsequently, Becker and Constant2 showed that tonography could be successfully performed on these animals with topical anesthesia only. The purpose of the present study was to find out whether, and to what extent, general anesthesia induces changes in the dynamics of the aqueous humor. To this end we have measured the coefficient of facility of outflow (C), the rate of aqueous flow (F), the episcleral venous pressure (Pv), and the ocular rigidity (K) in normal rabbits with and without general anesthesia. In view of the large variation in response of different species to anesthetic drugs, the reader is cautioned against assuming that the results found in rabbits necessarily apply to man.

The effects of general anesthesia on intraocular pressure

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