In about one-fourth to one-third of the cases of fatal multiple myeloma there is infiltration of characteristic myeloma cells in the viscera or other soft tissues.1 Almost any part of the body may be susceptible. Infiltrations have been found in the kidneys, liver, heart, skin, subcutaneous tissue, tonsils, thyroid, testes, ovaries, pleura, gastrointestinal tract, pancreas, uterus, adrenals, and dura.* This paper reports the occurrence of myelomatous infiltrates within the vascular and fibrous tunics of the eye.
In 1918, Stock3 reported a myeloma of the choroid in an eye which was enucleated during life. This was a heavily vascularized tumor, replacing part of the posterior choroid and extending from the disc almost to the lens. The tumor was encapsulated by fibrous connective tissue, with degeneration of the overlying retina. The predominant cell was described as similar to the plasma cell. The concomitant diagnosis of multiple myeloma was not established.
BRONSTEIN M. Ocular involvement in Multiple Myeloma. AMA Arch Ophthalmol. 1956;55(2):188-192. doi:10.1001/archopht.1956.00930030190004