In an effort to obtain addittional evidence of the importance of prior or concurrent hemolytic streptococcal infection in the etiology of uveitis, Leopold and Dickinson1 measured the antihyaluronidase and antistreptolysin titers in 63 cases of uveitis chosen at random from the ward service at the Wills Eye Hospital. They pointed out that in Woods' * classification of endogenous uveitis into granulomatous and nongranulomatous types the hemolytic Streptococcus has been suggested as the principal offender in the latter type.
Characteristically, the growing hemolytic Streptococcus secretes into the surrounding tissue a number of independently acting extracellular substances, among the most important of which are streptococcal hemolysin (or streptolysin) and streptococcal hyaluronidase.4 Being protein in nature, these substances can act as antigens and produce specific antibodies in the blood stream.† These antibodies are present in at least low titer in the serum of most adults (for all mankind is more or less
HALLETT JW, LEOPOLD IH, INWALD S. Streptococcal Antihyaluronidase in Uveitis and Primary GlaucomaTurbidimetric Measurement. AMA Arch Ophthalmol. 1956;55(3):313-319. doi:10.1001/archopht.1956.00930030317002