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Article
March 1956

Cataracts in Vitamin E DeficiencyAn Experimental Study in the Turkey Embryo

Author Affiliations

College Station, Texas; Galveston, Texas; College Station, Texas
From the Departments of Biochemistry and Nutrition and Poultry Husbandry, Agricultural and Mechanical College of Texas, College Station, Texas, and the Laboratory of Experimental Pathology, University of Texas Medical Branch, Galveston, Texas.

AMA Arch Ophthalmol. 1956;55(3):346-355. doi:10.1001/archopht.1956.00930030350006
Abstract

Nutritional deficiencies in relation to disorders of the eye have been described by many workers.* Cataracts in rats fed a riboflavin-deficient diet were described in 1931 by Day, Langston, and O'Brien.3 Curtis and co-workers,4 in 1932, produced cataracts in rats with a tryptophan-deficient diet. As far as we know, these are the only true primary deficiencies that have resulted in cataract formation.

The relation of vitamin E to retrolental fibroplasia was suggested by Owens and Owens5 in 1939. Callison and Orent-Keiles,6 in 1951, observed a lesion in embryos from rats fed vitamin E-deficient diets which suggested retrolental fibroplasia. Cataracts were described in 1954 by Ferguson, Atkinson, and Couch7 in turkey embryos obtained from hens fed a practical-type diet low in vitamin E. A similar lesion has occurred in turkey embryos obtained from hens fed a synthetictype diet deficient in vitamin E. The pathologic changes in

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