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April 1956

Perfusion in Vitro of Ten Glaucomatous Eyes

Author Affiliations

Ghent, Belgium
From the Ophthalmological Clinic of the University of Ghent; Director, Prof. J. François, M.D.; Researcher of the Belgian National Funds for Scientific Research (Dr. Rabaey).

AMA Arch Ophthalmol. 1956;55(4):488-502. doi:10.1001/archopht.1956.00930030492005

In a previous communication,1 we have reported the study, by means of perfusion, of the facility of outflow (C) in enucleated human eyes; normally this value equals 0.25, the resistance to the outflow (R=1/C) equaling 4. These values are in good agreement with those found clinically with the aid of tonography. In view of the fact that our experiments were performed under such conditions as to exclude all circulatory and nervous influences, it is clear that the outflow of the perfusion fluid depends solely on the anatomical condition of the scleral trabeculum.

We have also been able to show that the facility of outflow is directly proportional to the depth of the anterior chamber: The average curve of the outflow resistances as a function of this depth (Fig. 1), obtained after the study of 30 normal eyes, demonstrates this fact very well.

In the present article, we

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