In the past, considerable emphasis has been placed on the conflict between the neurovascular and the mechanical theory of glaucoma. According to the first theory, primary glaucoma arises from a disturbance of the neurovascular system of the eye, whereas according to the mechanical theory it depends on alterations in the mechanics of aqueous humor flow. This conflict is particularly evident in congestive glaucoma (narrow-angle glaucoma), whereas in chronic simple glaucoma (wide-angle glaucoma) the two theories are more easily reconciled.
The detection of the aqueous veins (1941) and the introduction of tonography (1950), giving glaucoma research a new impetus, have led most authorities to agree that in chronic simple glaucoma an obstruction, type unknown, is present somewhere between the anterior chamber and the deep or superficial scleral veins. The immediate cause of this obstruction is most likely either a vasoconstriction or a sclerosis of the angle or adjacent structures. The ultimate
CAMBIAGGI A, SPURGEON WM, SPURGEON R. Diurnal Changes in Eosinophile CountComparison with Changes in Intraocular Pressure, Tonographic Values, and Aqueous Veins. AMA Arch Ophthalmol. 1956;55(6):765-778. doi:10.1001/archopht.1956.00930030769002