There are two distinct and specific vascular lesions associated with diabetes mellitus in man, the retinal capillary microaneurysm and the glomerular nodule. The two may be found concomitantly in many diabetics, and some investigators have assumed these lesions to be similar. I feel that the retinal capillary microaneurysm, found almost exclusively in diabetes mellitus, is quite different from the specific nodule of intercapillary glomerulosclerosis. Both lesions have thus far been found only in man, and neither has been reliably produced in experimental animals.*
This paper attempts to clarify the relationship between the specific retinal and renal lesions with regard to chronology, pathogenesis, and specificity.
The ophthalmoscopic appearance of diabetic retinopathy is variable (Fig. 1).One of the earliest signs, if not the earliest sign, of diabetic retinopathy is the appearance of ophthalmoscopically visible capillary microaneurysms and punctate hemorrhages. These are located in the inner nuclear and outer plexiform
VOLK D. Dissimilarity of Retinal Microaneurysm and Glomerular Nodule in Diabetes. AMA Arch Ophthalmol. 1956;56(2):188-193. doi:10.1001/archopht.1956.00930040196005