Nature of Collagen Diseases Collagen diseases may be characterized as a group of disorders of unknown etiology that have in common histologic alterations of the connective tissues. They are of particular interest to the ophthalmologist because they frequently produce ocular changes. A typical connective tissue lesion in these diseases is fibrinoid degeneration. This common histopathologic change does not indicate a common etiology. Connective tissue may respond to a large variety of traumatic agents with only a few nonspecific reactions; thus various stimuli can produce the same changes in connective tissue. The reactions demonstrated by connective tissue are necrosis, fibrinoid alteration, cellular infiltration, sclerosis, proliferation, or various combinations of these.
Nature of Collagen Diseases Klemperer has defined these collagen diseases as clinically unrelated conditions which are similar only in that most of them appear to be due to a hypersensitivity reaction and all have a peculiar fibrinoid degeneration of connective tissue. It is thought that
LEOPOLD IH. The Therapy of Collagen Diseases. AMA Arch Ophthalmol. 1956;56(4):577-586. doi:10.1001/archopht.1956.00930040585007