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Article
January 1957

Anti-Toxoplasma Precipitins in Aqueous HumorNew Application of the Agar-Diffusion Technique

Author Affiliations

Bethesda, Md.
Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.

AMA Arch Ophthalmol. 1957;57(1):52-57. doi:10.1001/archopht.1957.00930050060013
Abstract

The Toxoplasma dye test of Sabin and Feldman,1 which is the mainstay of the present diagnostic regimen in presumptive ocular toxoplasmosis, appears to be inadequate on a number of accounts. Although Woods,* has recently shown that a serum titer of 1:64 is statistically significant in a group of adult patients with granulomatous uveitis, there is no definite proof that a given lesion in the uveal tract of such a patient is due to toxoplasmosis, as opposed to one of the other common granulomatous infections. The simultaneous existence of a positive serum dye test titer, due, perhaps, to a previous systemic infection with Toxoplasma, and a granulomatous uveitis due, for example, to tuberculosis, is a real possibility. Woods, moreover, stated that 25% of a nonuveitis control group which was studied serologically at the Johns Hopkins Hospital also showed positive dye tests at a titer of 1:64. Pursuant to a study

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