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January 1957

Elaboration of Bicarbonate Ion in Intraocular FluidsII. Vitreous Humor, Normal Values

Author Affiliations

Department of Research, Wills Eye Hospital, and the Department of Physiological Chemistry, Graduate School of Medicine, University of Pennsylvania.

AMA Arch Ophthalmol. 1957;57(1):85-89. doi:10.1001/archopht.1957.00930050093017

The vitreous humor is considered to be an important reservoir in the diffusional exchange of substances with the aqueous humor of the posterior chamber. Indeed, Christiansson and Palm1 and Kinsey and Palm,2 as well as Friedenwald and Becker,3 have shown that failure to take into account the dynamic properties of the chemical components of the vitreous humor in diffusional exchange with those in the aqueous humor leads to inaccurate estimates of the rate of flow of aqueous humor. Furthermore, determination of the distribution of substances in the different sections of the vitreous humor gives some idea as to the routes by which they enter. Thus, Duke-Elder and Davson,4 by a modification of the technique employed by Adler,5 concluded from the uniform distribution of glucose in the vitreous humor under normal conditions and when the blood sugar level was high that glucose diffuses into the vitreous

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