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January 1957

Cytomegalic Inclusion Disease

Author Affiliations

Portland, Ore.
From the Departments of Ophthalmology and Pathology, University of Oregon Medical School Hospitals and Clinics.

AMA Arch Ophthalmol. 1957;57(1):90-99. doi:10.1001/archopht.1957.00930050098018

Cytomegalic inclusion disease is a multisystem virus disease which is typified pathologically by an inclusion-cointaining giant cell that appears predominantly in epithelial linings of visceral and cerebral epithelium. It occurs most commonly in the newborn but may involve any age group and generally runs a fatal course. Until recently it has been recognized only at autopsy. Descriptions of this disorder date back as far as 1904, but not until recent years has it evolved as a disease entity of clinical importance.*

In infants its time of onset is somewhat variable, which suggests that it may be contracted either in utero or postnatally. Wyatt and co-workers, in summarizing 66 cases, reported 5 in stillborn babies, 10 in newborns, and the majority of the remainder in infants under 12 months of age.3

Since this is a multisystem disease in which no one system is always involved, the clinical characteristics are somewhat

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