Chloramphenicol (Chloromycetin), administered either orally or as a 1% ointment, has been shown to be an effective therapeutic agent in the treatment of trachoma (Holland, 1954). The quickest and most efficient method of securing high tissue concentration of the antibiotic for arresting the disease is a combination of local and oral treatment.
This method also presents many advantages both in simplicity and ease of administration, for there are few patients who cannot take 4 to 6 capsules of chloramphenicol daily for 10 days and apply the ointment to their eyes four times a day for a month or two. But the main drawback to this treatment is its expense. If the capsules are omitted to reduce this expense, then the application of the ointment must be continued for a minimum of five months. This prolonged treatment is enough to daunt many who have neither the patience nor the persistence to
HOLLAND RWB. The Treatment of Trachoma with Subconjunctival Injections of Chloramphenicol. AMA Arch Ophthalmol. 1957;57(2):214-217. doi:10.1001/archopht.1957.00930050224008