Mikulicz's disease of the lacrimal gland is a rare disease of unknown etiology. Four specimens of this disease, found in the files of the Eye Pathology Department of the Massachusetts Eye and Ear Infirmary since 1896, are reported.
Johann Mikulicz1 first described, in 1888, a chronic self-limited disease of unknown etiology involving the lacrimal and salivary glands. Clinically the patient presented painless swelling of the lacrimal, salivary, and palatine glands. No decrease in the function of these glands was noted: Indeed, copious salivation was described. Microscopic examination revealed the tissue of the submaxillary gland to consist primarily of small round cells. These cells lay close together or separated by a fine reticulum. Mitotic figures were seen in single large cells. Imbedded in the small round cells were apparently unchanged acini of the salivary gland. A similar picture was found on examining the lacrimal gland. This author rejected as further
MILAM DF. Mikulicz's Disease of the Lacrimal Gland. AMA Arch Ophthalmol. 1957;57(2):236-240. doi:10.1001/archopht.1957.00930050246012