The study of the microenvironment in inflammation and edema is a new field. Traditionally this region has been regarded correctly as a defense curtain, since it inhibits the spread of infection. The preservation of this membrane has been considered a basic surgical necessity.
The advent of the antibacterial drugs has produced a change in thought about this defense barrier. These substances are of little value in the treatment of abscesses, walled-off cellulitis, and similar inflammatory processes. Being carried by the blood, the antibacterial drugs cannot pass through the membrane from without anymore than can pathogenic bacteria from within.
The edema fluid present in inflammation and in edema alone contains large quantities of fibrin. Coagulation of this substance in the tissue fluids and the formation of thrombi in the arteries, capillaries, veins, and lymphatics help to localize the damaged area. This localizing process, in which precipitation of fibrin occurs, produces what
MILLER JM, PARKE DW, SURMONTE JA, GINSBERG M, ABLONDI FB. The Use of the Antibacterial Drugs and StreptokinaseAdministered Intramuscularly in Enucleation of the Eye.. AMA Arch Ophthalmol. 1957;57(2):241-244. doi:10.1001/archopht.1957.00930050251013