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March 1957

Serum Proteins and Total Glucosamine in Diabetic Retinopathy and Glomerulosclerosis

Author Affiliations

From the Wilmer Ophthalmological Institute of The Johns Hopkins University and Hospital. J. B. Collip Foundation Research Fellow, McGill University and Department of Ophthalmology, Montreal General Hospital (Dr. Lerman).

AMA Arch Ophthalmol. 1957;57(3):354-360. doi:10.1001/archopht.1957.00930050366006

The increase in the life expectancy of diabetics which has occurred in the post-insulin era, and which has been further augmented by the general advances in the understanding and treatment of metabolic disorders, has led to an increase in the degenerative complications of diabetes. Such is apparently the case with diabetic retinopathy, a complication which intimately concerns the ophthalmologist. Friedenwald2 and Vogelius,3 among others, have reported a marked increase in the incidence of retinopathy in the patients they studied, and, although there is still a good deal of controversy regarding the relationship of retinal disease to the degree of control of blood sugar, it is now generally accepted that the most important factor is the duration of the diabetes. The histopathological picture of diabetic retinal disease has been well defined by the excellent studies carried out by Ballantyne and Loewenstein,4 Ashton,5 and Friedenwald,2,6 and the

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