A prodromal meningismal episode, followed by nontraumatic bilateral uveitis, followed later by vitiligo, alopecia, dysacousia, and poliosis are the essential features of the Vogt-Koyanagi syndrome.1 If retinal detachment is detected in the course of the illness, the diagnosis has been made.of Harada's disease.2,3 Recent authors, however, describe these syndromes as variations in severity of a single disease.4,5 This report presents a case of severe headache, nausea and vomiting, and bilateral nontraumatic uveitis followed in several months by the appearance of poliosis and alopecia. This case is noteworthy for its features of both the Vogt-Koyanagi syndrome and Harada's disease, for its successful outcome under therapy, and for an unusual problem of differential diagnosis.
Report of a Case
A 36-year-old white woman was admitted to the neurological service complaining of headaches and nausea and vomiting of two weeks' duration. There was bilateral edema of the optic nerve heads. In
BRONSTEIN M. Vogt-Koyanagi-Harada DiseaseTreatment with Prednisone. AMA Arch Ophthalmol. 1957;57(4):503-507. doi:10.1001/archopht.1957.00930050515003