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May 1957

Oxygen Studies in Retrolental FibroplasiaV. The Effect of Rapid vs. Gradual Withdrawal from Oxygen on the Mouse Eye

Author Affiliations

From the Retrolental Fibroplasia Research Laboratory, District of Columbia General Hospital.

AMA Arch Ophthalmol. 1957;57(5):724-729. doi:10.1001/archopht.1957.00930050736013

It is now generally accepted from abundant clinical1,2 and experimental3-5 data that the over-use of oxygen is an important and probably the principal factor in the development of retrolental fibroplasia. There are, however, several controversial factors which are thought to influence the action of oxygen on the premature retina. One of these is the rate of withdrawal from the initial exposure to oxygen. Prolonged gradual withdrawal from oxygen to minimize or avoid the retinal damage produced by oxygen has been advocated principally by Szewczyk6 and Bedrossian and co-workers.7

This report is based on experiments designed to evaluate the effect of gradual versus rapid withdrawal from oxygen in the mouse eye. The data show that the additional oxygen administered during a period of gradual withdrawal frequently represented that added amount of oxygen necessary to make an initial nontoxic exposure to oxygen injurious.

Subjects and Methods 

Experiment I. 

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