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Article
July 1957

Syndrome of External Ophthalmoplegia, Ataxia, and Areflexia (Fisher)Ocular Manifestations in Acute Idiopathic Polyneuritis (Guillain-Barré Syndrome); Report of Two Cases

Author Affiliations

Baltimore
From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital.

AMA Arch Ophthalmol. 1957;58(1):109-114. doi:10.1001/archopht.1957.00940010121010
Abstract

In July, 1956, Fisher1 described three cases of an acute illness characterized by total external ophthalmoplegia, severe ataxia, and areflexia. He noted that this syndrome was related to acute idiopathic polyneuritis. The presenting symptoms and signs in these cases were alarming until the benign course of the disease was realized. It was his report that enabled us to recognize the nature of the illness in our cases. Fisher was unable to find specific reports of similar cases. We think that individual instances belonging to this group merit description, and two such cases are here presented.

Case 1 (The first patient was referred by Dr. Arthur B. King).  —A 38-year-old white male construction worker enjoyed good health until Oct. 24, 1956, when he developed a sore throat. This progressed despite two injections of penicillin given during the next two days. Although he felt bad, he continued working. He remained in bed

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