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August 1957

Comparative Electroretinographic Studies in Congenital Night Blindness and Total Color Blindness

Author Affiliations

Bethesda, Md.
Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.

AMA Arch Ophthalmol. 1957;58(2):174-182. doi:10.1001/archopht.1957.00940010186003

In the analysis of the human electroretinogram, the study of subjects with congenital night blindness and total color blindness is of great value. The absence of specific electroretinographic components in these anomalies simplifies the complex pattern of response, allows a more detailed investigation of the remaining components, and aids in the analysis of the photopicscotopic nature of the different waves. However, the few investigations which deal with the electroretinogram in congenital night blindness and total color blindness have studied each condition separately; therefore, no direct comparison has been made between their electroretinographic responses.

The purpose of this study is to investigate quantitatively the influence of dark-adaptation and stimulus intensity on the electroretinogram of normal, congenitally night-blind, and totally color-blind subjects,* examined under identical experimental conditions.

Subjects  The night-blind subject is a 28-year-old married white woman. She has been aware of poor night vision in both eyes since childhood, nonprogressive in

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