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September 1957

Nevoxanthoendothelioma with Ocular InvolvementA Report of Two Cases

Author Affiliations

From the Department of Surgery (Ophthalmology), The University of Chicago.

AMA Arch Ophthalmol. 1957;58(3):321-327. doi:10.1001/archopht.1957.00940010333001

Nevoxanthoendothelioma is a comparatively uncommon benign dermatologic disease characterized by the appearance in infants of one or more discrete bright-orange nodules on the skin. No abnormality of serum lipid values can be demonstrated; physical examination, except for the skin tumors, is negative, and there is a tendency for slow spontaneous disappearance of the lesions. Visceral involvement is usually not observed. The skin lesions are usually observed at birth or shortly thereafter and vary in number from one or two to many hundreds. They vary in size from 3 to 10 mm. in diameter and are 3 to 4 mm. above the surrounding skin surface.

These cutaneous tumors disappear at the age of 3 or 4 years, leaving a slightly glazed flat scar. There is no residual systemic disease.

The disease has been described as nevoxanthoendothelioma only in the past 10 or 12 years. Prior to that, examples of the condition

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