Persistent pupillary membrane remnants are so common that they are seen frequently by every ophthalmologist. They are usually of no clinical significance. However, rare cases may show extensive membrane remnants with associated lens opacities, producing visual disturbances.
The purpose of this paper is to describe a patient with an almost complete persistence of the pupillary membranes bilaterally, progressive lens opacities, and increased corneal diameters. The relatives and ancestors of this patient had a high incidence of persistent pupillary membranes and associated anomalies. The fact that this type of iris anomaly can have an hereditary basis is not generally recognized.
The incidence of persistent pupillary membrane has been given by Stahli1 as 30.6%. In addition to the classical strands arising from the collarette, minute remnants on the anterior capsule are extremely common (Rumbaur),2 being seen in 35% of cases. There is a wide variety of manifestations of this type
CASSADY JR, LIGHT A. Familial Persistent Pupillary Membranes. AMA Arch Ophthalmol. 1957;58(3):438-448. doi:10.1001/archopht.1957.00940010450021