Although many fungus infections of the eye and the orbit are never diagnosed, their importance is being recognized more and more. It seems that fungus infections of the eye are observed rather frequently, while infections of the orbit occur rarely.
Baker1 reported two cases of acute orbital cellulitis caused by mucormycosis. This organism usually is considered nonpathogenic, but the author was of the opinion that uncontrolled diabetes and leukemia and the injudicious use of antileukemic drugs, some antibiotic drugs, and cortisone might render a patient susceptible to the invasion. The role that antibiotic and corticosteroid drugs play in the etiology of fungus keratitis has not been determined definitely; however, there is increasing evidence to indict both, especially the corticosteroid group. Mitsui and Hanabusa2 reported four cases of fungus keratitis following topical ophthalmic use of a corticosteroid ointment, and Ley and Sanders3 reported three cases. Antibiotic and corticosteroid
VEIRS ER, DAVIS CT. Fungus Infections of the Eye and the Orbit. AMA Arch Ophthalmol. 1958;59(2):172-176. doi:10.1001/archopht.1958.00940030038002