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Article
February 1958

Idiopathic Atrophy of the Epithelial Layers of the Iris and Ciliary BodyA Clinical Study

Author Affiliations

Philadelphia
From the Department of Ophthalmology, Hospital of the University of Pennsylvania, and The Children's Hospital of Philadelphia. Visiting Fellow, Ophthalmological Hospital of the Medical Academy, Düsseldorf, Germany (Dr. Fleischhauer). Director Dr. Ernst Custodis, Professor of Ophthalmology.

AMA Arch Ophthalmol. 1958;59(2):216-228. doi:10.1001/archopht.1958.00940030084007
Abstract

Introduction  This paper reports 97 eyes (49 patients), all showing a group of intraocular pigment changes due to an idiopathic atrophy of the retinal layers of the iris and probably the ciliary body, which we believe comprise a single clinical entity. The condition is often associated with glaucoma. Most of the pigment changes are well known, but usually they have been described with little or no attempt to correlate them into a disease complex. They consist of (1) punctate pigment deposition on the corneal endothelium, usually in the form of a Krukenberg spindle; (2) speckling of the anterior surface of the iris with pigment; (3) pigmentation of the trabecular area of the anterior chamber; (4) pigment on the posterior surface of the lens near the equator, occasionally in the form of a ring, and (5) atrophy of the epithelial layers of the iris. Glaucoma that follows a chronic simple (open-angle)

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