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March 1958

Studies on Simulated Vitreous HemorrhagesII. The Effects of Lytic Enzymes, Surface-Active Agents, and Urea

Author Affiliations

San Francisco
From the Francis I. Proctor Foundation for Research in Ophthalmology, University of California Medical Center.

AMA Arch Ophthalmol. 1958;59(3):333-336. doi:10.1001/archopht.1958.00940040039003

There have been a number of reports on the modification of the vitreous body by lytic enzymes but few, if any, on the effect of surface-active agents (surfactants) and urea.

In the early work with hyaluronidase, von Sallmann1 and Pirie2 found that this enzyme produced considerable inflammation in the vitreous. Subsequent purification of the hyaluronidase has reduced the amount of inflammation produced. Planten and Hoppenbrouwers,3 using a small amount of hyaluronidase, found little inflammatory reaction after intraocular injection.

A preparation of streptokinase and streptodornase (Varidase) has been studied, with somewhat conflicting results. Jukovsky4 claimed that streptokinase-streptodornase produced lysis of blood clots in the anterior chamber of rabbit eyes, while Friedman5 found that it produced very little lysis and caused a damaging inflammation. O'Rourke6 showed that blood clots were slowly lysed by streptokinase-activated plasminogen and that at concentrations greater than 50,000 units per cubic centimeter

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