In the past several years, the role of histamine as the culprit accountable for the discomforts of inflammatory processes in general has been brought to light. There is an awareness of the association of anaphylactic and allergic reactions with histamine. It has been shown also that histamine, a product of the amino acid histadine, which is present in all complete protein, is released from tissue cells in many abnormal states, particularly trauma. There is, however, as yet, no definitely proven function of histamine in normal physiological states.1 It is known that histamine causes a vasodilatation of the arterioles and capillaries, and with sufficient histamine release the permeability of the vessels is altered. The result is a transudation of plasma, protein, and fluid into the extracellular spaces, producing edema and inflammatory exudate about the blood vessels.2 The triple response of Lewis is a good example of local histamine release.
WEIL VJ, ELISAOPH I, LAVAL J. Cataract Wound Healing in the Rabbit EyeAn Experimental Evaluation of the Effects of Antihistamines on Corneal Wound Healing. AMA Arch Ophthalmol. 1958;59(4):551-558. doi:10.1001/archopht.1958.00940050107013