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January 1959

Ocular Pressure in Experimental Cross CirculationA Preliminary Report

Author Affiliations

Los Angeles; Baltimore
From the Wilmer Ophthalmological Institute of The Johns Hopkins University and Hospital, Baltimore. This work was presented in part at the Wilmer Resident's Association Meeting, March 28, 1958.

AMA Arch Ophthalmol. 1959;61(1):102-109. doi:10.1001/archopht.1959.00940090104015

It has been observed since at least 1924 that the ocular pressure of one eye may be influenced by alterations in the pressure of the second eye.1 The phrase "ophthalmotonic consensual reaction" has been used to describe this phenomenon.1 The reaction has been studied in both humans and animals2-4 and was recently characterized in some detail by Prijot and Stone,5 who showed that in rabbits compression of one eye could elicit a fall in ocular pressure in the second, undisturbed, eye. This reduction was related to a decrease in aqueous flow while the facility of outflow remained relatively constant. The observation that systematically administered atropine blocked the consensual ophthalmotonic reaction suggested that the reaction was mediated, at least in part, by the autonomic nervous system.

Prijot and Stone5 observed that the maximum effect of flow reduction upon ocular pressure occurred between 15 and 20 minutes

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