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Article
February 1959

Metastases of the Retinoblastoma to the Central Nervous SystemAdvisability of a Combined Intraorbital and Intracranial Removal of the Affected Optic Nerve

Author Affiliations

Bethesda, Md.
From the National Institute of Neurological Diseases and Blindness, National Institutes of Health, U. S. Public Health Service, Department of Health, Education, and Welfare.

AMA Arch Ophthalmol. 1959;61(2):239-245. doi:10.1001/archopht.1959.00940090241008
Abstract

Retinoblastoma is a highly malignant neoplasm which originates from the neuroectodermal elements of the retina. In a proportion of cases, the tumor is congenital and it may be detected during the early months of life by clinical means. However, the commonest time when definitive diagnosis is made is about 2 years of age. The incidence of retinoblastoma was estimated by Weller1 as 1 in 34,000 births. The main principles of treatment consist of enucleation of the eye followed by radiation or radiotherapy alone. The true rate of complete recovery after institution of treatment is difficult to assess. In many of the published reports the authors do not follow their patients for a sufficient length of time to permit comprehensive evaluation.

We have attempted to review the literature published since 1945 of the documented cases of retinoblastoma that have been adequately followed. The criteria for accepting the reports required that

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