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March 1959

Cytomegalic Inclusion Disease UveitisReport of a Case with Isolation from Aqueous Humor of the Virus in Tissue Culture

Author Affiliations

New York
Author's present address: University of Oregon Medical School, Department of Ophthalmology, 3181 S.W. Sam Jackson Park Rd., Portland 1, Oregon.

AMA Arch Ophthalmol. 1959;61(3):376-387. doi:10.1001/archopht.1959.00940090378007

Cytomegalic inclusion disease or salivary gland virus disease is a pathologic entity that has been known since 1904 by the large intranuclear and intracytoplasmic inclusionbearing cells,1 but it has recently been emphasized because the etiology has been clarified and its diagnosis has been facilitated by modern techniques. At first it was a pathologic rarity described only at autopsy and diagnosed as congenital syphilis2 and amebiasis.3 Later cases were described primarily as erythroblastosis fetalis,4 keratomalacia,5 whooping cough,6,7 and toxoplasmosis.8

The salivary gland virus was originally described as large inclusion-bearing cells resembling those of cytomegalic inclusion disease found in the salivary glands9 in a high percentage10 of adult animals of numerous species.11 It was found to be associated with a weak species-specific filtrable virus, transmissible to unborn or young animals for a few passages but not to adults,12 presumably because of

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