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Article
March 1959

Evaluation of Heparin Therapy of Senile Macular Degeneration

Author Affiliations

Columbus, Ohio

AMA Arch Ophthalmol. 1959;61(3):390-401. doi:10.1001/archopht.1959.00940090392009
Abstract

Heparin therapy has been recommended for senile macular degeneration, in the belief that this treatment may improve the nutrition of the degenerating region. A recent report1 states that more than half of a series of 23 patients treated with 100 mg. of heparin I. V. twice weekly showed eye improvement. This improvement consisted of such definite findings as increased visual acuity, disappearance of retinal hemorrhages, and shrinking of exudates. There were no control patients.

Our evaluation of heparin therapy was carried out on two separate groups of patients with senile macular degeneration. The larger group, consisting of 25 patients, were inmates of an old-folks' home. To be included in this group, the patient was required to have ophthalmoscopically visible senile macular degeneration. This excluded any patients with dense opacities of the clear ocular media. Details of each case are appended at the close of this paper. At the beginning

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