An allergic causation is believed primarily responsible not only for the obviously allergic reactions of the uvea occurring during serum sickness, angioneurotic edema, and other immediate forms of allergy but also for the inflammatory process characteristic of the rather common nongranulomatous, sterile form of endogenous uveal inflammation. Such delayed allergic reactions are thought to be of the microbial type. Autogenous allergy appears to be essential in the causation of sympathetic ophthalmia and in endophthalmitis phacoanaphylactica. In infectious granulomatous types of uveitis, such as tuberculosis, a secondary microbial allergy often alters and aggravates the inflammatory state.
The Basis for Allergy as a Cause of Uveitis
The belief that allergy is responsible for most attacks of nongranulomatous uveitis and that allergy can also markedly influence the course of the granulomatous forms of uveitis is more than speculation. Anatomically, the uvea provides an ideal shock organ, a fact that was utilized by early
COLES RS, THEODORE FH. Clinical Aspects of Uveal Hypersensitivity. AMA Arch Ophthalmol. 1959;62(2):223-229. doi:10.1001/archopht.1959.04220020049007