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August 1959

Ocular Manifestations of Pituitary Tumor in Cushing's Syndrome

Author Affiliations

Rochester, Minn.
Section of Ophthalmology (Dr. Kearns), Section of Medicine (Dr. Salassa), Section of Pathologic Anatomy (Dr. Kernohan), and Section of Neurologic Surgery (Dr. MacCarty), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

AMA Arch Ophthalmol. 1959;62(2):242-247. doi:10.1001/archopht.1959.04220020068010

The series of cases to be reported in this paper represent a most unusual group. Not only did the patients have an interesting association of pituitary tumor with Cushing's syndrome,1 but we think that the ocular findings are unusual enough to warrant presentation in the ophthalmic literature.

From discussions with colleagues and a review of the literature, it appears that ophthalmologists are not aware of the association of pituitary tumor with Cushing's syndrome. Furthermore, the belief still exists that a pituitary tumor in conjunction with Cushing's syndrome must be a basophil adenoma rather than a chromophobe adenoma. The opinion that basophil adenomas occur in Cushing's syndrome stems from the original observations made by Cushing,2 in 1932, on small basophilic tumors of the pituitary. He emphasized their possible role in the production of the syndrome bearing his name. Interest has continued in the relationship between the anterior pituitary and

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