Hereditary changes in the skin of the eyelids are rarely observed. Epiblepharon1 (folds of skin running horizontally across the lid), blepharochalasis (bagginess of the upper lids due to atrophy and relaxation of the tissues), and a condition simulating senile atrophy may fall into this category. Usher2 found 21 cases of unusual appearance of the skin of the eyelids in the five-generation pedigree of the kindred of two first cousins with congenital entropion; in 4 of these cases the skin changes were associated with entropion; in 9 other cases there was entropion alone. He concluded that there is a hereditary factor responsible for the skin changes and suggested that the entropion is secondary to skin anomaly.
Report of Case
The patient, 32 years of age, was examined by me in 1947, when she was 20, and again in 1951 and 1958. She presented no complaints, coming primarily for refraction.
Levitt JM. Hereditary Changes in Skin of the Eyelids. AMA Arch Ophthalmol. 1959;62(3):506-507. doi:10.1001/archopht.1959.04220030162021