Recent interest in psychopharmacology has led to extensive investigation of a number of types of drugs. The derivative of ergot known as d-lysergic diethylamide, or LSD-25, is one of the most thoroughly studied. This substance has been known to have pronounced effects upon the uterus, vagina, and bronchi and to cause mydriasis, tachycardia, rise in temperature, and other autonomic effects.1 Hoffman,2 in 1943, was the first to report psychic effects of the drug, after he had accidentally ingested a small quantity of it. These have been found to include mood changes, schizoid states, and, most important from the ophthalmological standpoint, visual hallucinations.
The doses required for production of hallucinations in man are extremely minute, as little as 0.5μg. to 1.0μg. per kilogram of body weight being effective.3 Larger doses are required in schizophrenic patients.4
Recently Apter and Pfeiffer5 reported their observation that upon administration
JACOBSON JH, GESTRING GF. Spontaneous Retinal Electrical Potentials. AMA Arch Ophthalmol. 1959;62(4):599-603. doi:10.1001/archopht.1959.04220040061008