It is now widely held that the treatment of chronic simple glaucoma should be conservative, because it is realized that the surgical results are very indifferent in this form of glaucoma as opposed to the angleclosure variety. Present-day research is directed toward finding the etiology of this condition and into the evolution of new remedies which may help the conservative control of glaucoma once it is established. While there is no universal agreement that the changes at the optic nerve head and the changes in intraocular pressure run in parallel, it is nevertheless agreed that a rise in the intraocular pressure is to be avoided, and, even though this does not always completely arrest the glaucomatous process, there is evidence to support the notion that control of the intraocular pressure constitutes the only known means by which the pathological process can be influenced.
A number of new powerful cholinesterase inhibitors
DRANCE SM, Carr F. Effect of Demecarium Bromide (BC 48) on Intraocular Pressure in Man. AMA Arch Ophthalmol. 1959;62(4):673-678. doi:10.1001/archopht.1959.04220040135019